| Pair Name | Gossypol, Doxorubicin | ||
| Phytochemical Name | Gossypol (PubChem CID: 3503 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Gossypol, Doxorubicin | |||
| Disease Info | [ICD-11: 2B5A] | Biphasic synovial sarcoma | Investigative | |
| Biological Phenomena | Induction-->Blockade of cell cycle in S phase | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| In Vitro Model | SW982 | Biphasic synovial sarcoma | Homo sapiens (Human) | CVCL_1734 |
| Result | Combination therapy with L gossypol and low-concentration doxorubicin inhibited cell proliferation and induced apoptosis in SW982 HSSCs at a significantly greater level compared with either treatment alone | |||
| No. | Title | Href |
|---|---|---|
| 1 | Combination of L-gossypol and low-concentration doxorubicin induces apoptosis in human synovial sarcoma cells. Mol Med Rep. 2015 Oct;12(4):5924-32. doi: 10.3892/mmr.2015.4127. | Click |
